Acetohexamide

 Acetohexamide (trade name Dymelor) is a first-generation sulfonylurea medication used to treat diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.

Acetohexamide
Acetohexamide.svg
Acetohexamide ball-and-stick.png
Clinical data
Trade namesDymelor
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa602021
ATC code
  • A10BB31 (WHO)
Pharmacokinetic data
Protein binding90%
Identifiers
IUPAC name
  • 1-[(4-acetylbenzene)sulfonyl]-3-cyclohexylurea 4-acetyl-N-(cyclohexylcarbamoyl)benzenesulfonamide
CAS Number
  • 968-81-0 check
PubChem CID
  • 1989
IUPHAR/BPS
  • 6793
DrugBank
  • DB00414 check
ChemSpider
  • 1912 check
UNII
  • QGC8W08I6I
KEGG
  • D00219 check
ChEBI
  • CHEBI:28052 check
ChEMBL
  • ChEMBL1589 check
CompTox Dashboard (EPA)
  • DTXSID7020007 Edit this at Wikidata
ECHA InfoCard100.012.301 Edit this at Wikidata
Chemical and physical data
FormulaC15H20N2O4S
Molar mass324.40 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point188 to 190 °C (370 to 374 °F)
SMILES
  • O=C(NC1CCCCC1)NS(=O)(=O)c2ccc(C(=O)C)cc2
InChI
  • InChI=1S/C15H20N2O4S/c1-11(18)12-7-9-14(10-8-12)22(20,21)17-15(19)16-13-5-3-2-4-6-13/h7-10,13H,2-6H2,1H3,(H2,16,17,19) check
  • Key:VGZSUPCWNCWDAN-UHFFFAOYSA-N check
  (verify)

Mechanism of actionEdit

Acetohexamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently.[1] The pancreas must produce insulin for this medication to work. For this reason, acetohexamide is not used to treat diabetes mellitus type 1.

RisksEdit

Oral hypoglycemic drugs, including acetohexamide, have been associated with increased cardiovascular mortality. Talk to your doctor about the possible risks, benefits, and alternatives of using this drug for your condition.[2]

This article uses material from the Wikipedia article
 Metasyntactic variable, which is released under the 
Creative Commons
Attribution-ShareAlike 3.0 Unported License.