Gliquidone

 Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic medication in the sulfonylurea class. It is classified as a second-generation sulfonylurea. It is used in the treatment of diabetes mellitus type 2. It is marketed by the pharmaceutical company Boehringer Ingelheim (Germany).

Gliquidone
Gliquidone.svg
Clinical data
Trade namesGlurenorm
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • C
Routes of
administration		Oral (tablets)
ATC code
  • A10BB08 (WHO)
Legal status
Legal status
  • UK: POM (Prescription only)
  • In general: ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityHigh (Tmax = 2–3 hours)
MetabolismExtensive hepatic
Onset of action1–1.5 hours
ExcretionBiliary (95%), renal (5%)
Identifiers
IUPAC name
  • 1-cyclohexyl-3-[4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxoisoquinolin-2-yl)ethyl]phenyl]sulfonylurea
CAS Number
  • 33342-05-1
PubChem CID
  • 91610
DrugBank
  • DB01251 check
ChemSpider
  • 82719 check
UNII
  • C7C2QDD75P
KEGG
  • D02430 check
ChEMBL
  • ChEMBL383634 check
CompTox Dashboard (EPA)
  • DTXSID4023096 Edit this at Wikidata
ECHA InfoCard100.046.770 Edit this at Wikidata
Chemical and physical data
FormulaC27H33N3O6S
Molar mass527.64 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • O=C(NC1CCCCC1)NS(=O)(=O)c2ccc(cc2)CCN4C(=O)c3c(ccc(OC)c3)C(C4=O)(C)C
InChI
  • InChI=1S/C27H33N3O6S/c1-27(2)23-14-11-20(36-3)17-22(23)24(31)30(25(27)32)16-15-18-9-12-21(13-10-18)37(34,35)29-26(33)28-19-7-5-4-6-8-19/h9-14,17,19H,4-8,15-16H2,1-3H3,(H2,28,29,33) check
  • Key:LLJFMFZYVVLQKT-UHFFFAOYSA-N check
  (verify)

ContraindicationsEdit

  • Allergy to sulfonylureas or sulfonamides
  • Diabetes mellitus type 1
  • Diabetic ketoacidosis
  • Patients that underwent removal of the pancreas
  • Acute porphyria
  • Severe liver disease accompanying with liver insufficiency
  • Several conditions (e.g., infectious diseases or major surgical intervention), when insulin administration is required
  • Pregnancy or breastfeeding[1]

PharmacokineticsEdit

Gliquidone is fully metabolized by the liver. Its metabolites are excreted virtually completely with bile (even with long-term administration), thus allowing the use of medication in diabetic patients suffering from kidney disease and diabetic nephropathy.[1]

This article uses material from the Wikipedia article
 Metasyntactic variable, which is released under the 
Creative Commons
Attribution-ShareAlike 3.0 Unported License.