Sorbinil

 Sorbinil (INN) is an aldose reductase inhibitor being investigated for treatment of diabetic complications including neuropathy and retinopathy.[3] Aldose reductase is an enzyme present in lens and brain that gets rid of excess glucose by converting it to sorbitol. Sorbitol accumulation can lead to the development of cataracts in the lens and neuropathy in peripheral nerves. Sorbinil has been shown to inhibit aldose reductase in human brain[4] and placenta[5] and calf[6] and rat lens.[5] Sorbinil reduced sorbitol accumulation in rat lens and sciatic nerve of diabetic rats orally administered 0.25 mg/kg sorbinil.[5]

Sorbinil
Structural formula of sorbinil
Ball-and-stick model of the sorbinil molecule
Names
IUPAC name
(4S)-6-Fluoro-2,3-dihydro-2’H,5’H-spiro[chromene-4,4’-imidazolidine]-2’,5’-dione
Other names
(S)-6-Fluorospiro(chroman-4,4'-imidazolidine)-2',5'-dione; CP 45634
Identifiers
CAS Number
  • 68367-52-2
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL7681
ChemSpider
  • 298991
ECHA InfoCard100.210.173 Edit this at Wikidata
IUPHAR/BPS
  • 7415
KEGG
  • D05893
PubChem CID
  • 337359
UNII
  • G4186B906P check
CompTox Dashboard (EPA)
  • DTXSID0023587 Edit this at Wikidata
InChI
  • InChI=1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1
SMILES
  • Fc3ccc2OCC[C@@]1(C(=O)NC(=O)N1)c2c3
Properties[1]
Chemical formula
C11H9FN2O3
Molar mass236.202 g·mol−1
AppearanceWhite to off-white powder
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

This article uses material from the Wikipedia article
 Metasyntactic variable, which is released under the 
Creative Commons
Attribution-ShareAlike 3.0 Unported License.