Torasemide

 Torasemide, also known as torsemide, is a diuretic medication used to treat fluid overload due to heart failure, kidney disease, and liver disease and high blood pressure.[1] It is a less preferred treatment for high blood pressure.[1] It is taken by mouth or by injection into a vein.[1]

Torasemide
Torasemide.svg
Torasemide 3D ball-and-stick crystal.png
Clinical data
Trade namesDemadex, Tortas, Wator, others
Other namesTorsemide
AHFS/Drugs.comMonograph
MedlinePlusa601212
License data
  • US DailyMed: Torsemide
Routes of
administration		By mouth, IV
Drug classLoop diuretic
ATC code
  • C03CA04 (WHO)
Legal status
Legal status
  • US: ℞-only
Pharmacokinetic data
Bioavailability80-90%
Protein bindingHighly bound (>99%).
MetabolismHepatic (80%)
Elimination half-life3.5 hours; Cirrhosis: 7-8 hours
Identifiers
IUPAC name
  • N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
CAS Number
  • 56211-40-6 check
PubChem CID
  • 41781
IUPHAR/BPS
  • 7312
DrugBank
  • DB00214 check
ChemSpider
  • 38123 check
UNII
  • W31X2H97FB
KEGG
  • D00382 check
ChEBI
  • CHEBI:9637 ☒
ChEMBL
  • ChEMBL1148 check
CompTox Dashboard (EPA)
  • DTXSID2023690 Edit this at Wikidata
ECHA InfoCard100.164.924 Edit this at Wikidata
Chemical and physical data
FormulaC16H20N4O3S
Molar mass348.42 g·mol−1
3D model (JSmol)
  • Interactive image
SMILES
  • CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cc(C)ccc2
InChI
  • InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) check
  • Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N check
 ☒check (what is this?)  (verify)

Common side effects include headache, increased urination, diarrhea, cough, and dizziness.[1] Other side effects may include hearing loss and low blood potassium.[1] Torasemide is a sulfonamide and loop diuretic.[1] Use is not recommended in pregnancy or breastfeeding.[2] It works by decreasing the reabsorption of sodium by the kidneys.[1]

Torasemide was patented in 1974 and came into medical use in 1993.[3] It is available as a generic medication.[2] In 2017, it was the 264th most commonly prescribed medication in the United States, with more than one million prescriptions.[4][5]

Medical usesEdit

It is used to treat fluid overload due to heart failure and high blood pressure.[1] Compared with furosemide, torasemide is associated with a lower risk of rehospitalization for heart failure and an improvement in New York Heart Association class of heart failure.[6][7][8] In heart failure it may be safer and more effective than furosemide.[9][10][11]

Adverse effectsEdit

No evidence of torasemide-induced ototoxicity has been demonstrated in humans.[12]

Loop diuretics, including torsemide, may decrease total body thiamine, particularly in people with poor thiamine intake, and this depletion may worsen heart failure. It is therefore reasonable to either also give thiamine supplements or to check blood thiamine levels in those being treated with chronic loop diuretics.[13]

ChemistryEdit

Compared with other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium loss.

NamesEdit

Torasemide is the recommended name of the drug (rINN) according to the (INN), which is the drug naming system coordinated by the World Health Organization. Torsemide is the official name of the drug according to the (USAN), which is the drug naming system coordinated by the USAN Council, which is co-sponsored by the American Medical Association (AMA), the United States Pharmacopeial Convention (USP), and the American Pharmacists Association (APhA).

This article uses material from the Wikipedia article
 Metasyntactic variable, which is released under the 
Creative Commons
Attribution-ShareAlike 3.0 Unported License.